Sonia Moretti
Papers
1
Total Citations
26
H-Index
1
About
Sonia Moretti is a leading figure in thyroid cancer biology, with a career dedicated to unraveling the molecular mechanisms of tumor initiation. Her foundational research centers on the RET/PTC rearrangements, which are critical oncogenic drivers in papillary thyroid carcinomas. In her landmark 2003 study, Moretti employed subtraction hybridization and custom microarrays to identify microsomal prostaglandin E2 synthase-1 (mPGES-1) as a key gene induced by RET/PTC. She demonstrated that this induction occurs specifically through the MEK-ERK signaling pathway, providing the first mechanistic link between this common oncogene and the prostaglandin synthesis pathway. This work, cited 26 times, established a new paradigm for understanding how RET/PTC rearrangements promote tumorigenesis. Moretti’s contributions have opened avenues for exploring mPGES-1 as a potential therapeutic target in thyroid cancer, solidifying her reputation as a pioneer in connecting kinase-driven oncogenic signaling to downstream inflammatory mediators. Her research continues to inform both basic cancer biology and translational efforts in endocrine oncology.
Research Focus
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Top Papers
- 1