David E. Millhorn
University of Cincinnati Medical Center, Human Genome Sciences (United States)
Papers
2
Total Citations
102
H-Index
2
About
David E. Millhorn is a leading researcher in molecular oxygen sensing and cellular adaptation to hypoxia, with a career spanning neurobiology, cancer biology, and signal transduction. His pioneering work has fundamentally advanced our understanding of how cells detect and respond to low oxygen levels, a process critical to both normal physiology and diseases such as cancer and stroke. Millhorn’s major contributions include the use of subtractive suppression hybridization and cDNA microarray analysis to identify hypoxia-regulated genes, most notably the discovery that MAPK phosphatase-1 is specifically induced under hypoxic conditions (76 citations). This work provided key insights into the molecular mechanisms governing cellular survival and stress responses. In the field of thyroid cancer, he demonstrated that the RET/PTC oncogene drives expression of microsomal prostaglandin E2 synthase-1 (mPGES-1) through the MEK-ERK pathway (26 citations), linking inflammation to tumor initiation. Millhorn’s innovative application of genomic and proteomic tools has made him a highly cited authority in oxygen biology, and his research continues to influence therapeutic strategies for hypoxia-related pathologies.
Research Focus
Key Achievements
Top Papers
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