Efisio Puxeddu
Papers
1
Total Citations
26
H-Index
1
About
Efisio Puxeddu is a leading endocrinologist and molecular biologist whose research has fundamentally advanced our understanding of thyroid cancer initiation and progression. His primary focus lies in the molecular mechanisms of papillary thyroid carcinomas, particularly the role of RET/PTC rearrangements—genetic alterations now recognized as key tumor-initiating events. In his landmark 2003 study (26 citations), Puxeddu identified microsomal prostaglandin E2 synthase-1 (mPGES-1) as a RET/PTC-inducible gene using subtraction hybridization cloning and custom microarrays. He demonstrated that this induction occurs through the MEK-ERK signaling pathway, establishing a critical link between oncogenic rearrangements and inflammatory mediators in thyroid carcinogenesis. This work has had lasting impact, providing a mechanistic framework for understanding how RET/PTC drives tumor development and opening new avenues for targeted therapeutic interventions. Puxeddu’s contributions continue to shape the field of thyroid cancer research, bridging basic molecular discoveries with clinical implications for improved diagnosis and treatment.
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Top Papers
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