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Shweta Mane is a biomedical engineer whose research focuses on the intersection of therapeutic ultrasound and neuroimaging, particularly in the context of thermal ablation for brain disorders. Her work critically examines the safety and efficacy of emerging ultrasound-based therapies, with a key contribution being her investigation of the biological effects on brain tissue outside the primary ablation zone. In her most-cited study, "What happens to brain outside the thermal ablation zones? An assessment of needle-based therapeutic ultrasound in survival swine" (2022, 4 citations), she addressed a critical gap in the field by evaluating the collateral damage to surrounding tissue—a concern analogous to isodose lines in stereotactic radiosurgery. This work, conducted in a large animal model, provides foundational evidence for the safe clinical translation of needle-based therapeutic ultrasound. Mane’s research is vital for advancing minimally invasive neurosurgical techniques, ensuring that thermal therapies like LITT and tcMRgFUS can be applied with greater precision and reduced risk. Her contributions are shaping the future of targeted brain treatments, making her a promising voice in neurotherapeutics.