Shuangyan Han
Papers
1
Total Citations
53
H-Index
1
About
Shuangyan Han is a leading figure in synthetic biology and protein engineering, with a specialized focus on the directed evolution of industrial enzymes in yeast systems. Her research centers on developing high-throughput screening platforms to accelerate the engineering of biocatalysts, particularly for lignocellulosic biomass degradation. Han’s most impactful work, a 2019 study on gel microdroplet–based high-throughput screening for directed evolution of xylanase-producing *Pichia pastoris*, has garnered 53 citations and represents a methodological breakthrough. By encapsulating single yeast cells in gel microdroplets, she enabled rapid, cost-effective selection of enzyme variants with enhanced activity, overcoming a key bottleneck in industrial biotechnology. This work has direct applications in biofuel production and sustainable chemical manufacturing. Han’s contributions have been recognized through her leadership in enzyme engineering projects and her role in advancing *P. pastoris* as a robust cell factory. Her innovative screening strategies continue to inspire researchers aiming to harness directed evolution for real-world biocatalytic solutions.
Research Focus
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Top Papers
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