Samuel Swisher‐McClure
Papers
16
Total Citations
365
H-Index
8
About
Samuel Swisher‐McClure is a leading radiation oncologist and clinical researcher whose work focuses on de-intensifying treatment for human papillomavirus (HPV)-related oropharyngeal cancer, a disease with rising incidence and excellent prognosis. His major contributions center on refining surgical and radiation strategies to reduce long-term toxicity without compromising oncologic outcomes. His landmark Phase 2 AVOID trial (167 citations) demonstrated that omitting the resected primary tumor bed from postoperative radiation after transoral robotic surgery (TORS) is safe and spares healthy tissue. He also showed that proton therapy significantly improves quality of life compared to conventional photon radiation for oropharynx cancer patients (48 citations). Swisher‐McClure has published extensively on oncologic outcomes after TORS, including in older patients and those with HPV-negative disease, and has investigated sex-based differences and patterns of recurrence. His work has been cited over 350 times, reflecting its influence on clinical guidelines and practice. By systematically identifying which patients can safely receive less aggressive therapy, he is helping to transform the standard of care for a growing population of cancer survivors.
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