Richard M. Caprioli
Papers
8
Total Citations
1,214
H-Index
8
About
Richard M. Caprioli is a pioneering analytical chemist and biomedical researcher whose career has fundamentally transformed how scientists visualize and identify proteins directly within biological tissues. He is best known for developing and advancing **MALDI imaging mass spectrometry (IMS)**, a revolutionary suite of techniques that enables spatially resolved molecular mapping of proteins, peptides, and lipids in intact tissue sections — without destroying the sample's architecture. Caprioli's foundational contributions include establishing tissue profiling by MALDI MS (252 citations) as a mainstream biomedical tool, and introducing on-tissue tryptic digestion coupled with IMS for direct protein identification from spatially discrete tissue regions (372 citations) — a method that dramatically expanded the biological insight obtainable from a single tissue section. His histology-directed profiling strategy (187 citations) further improved cellular specificity and throughput in human breast cancer analysis, while later innovations pushed spatial resolution to 1 μm laser spot diameters (185 citations), enabling near-single-cell imaging. Beyond methodology, his research has illuminated disease mechanisms, including lipid alterations in diabetic nephropathy (116 citations). His body of work has equipped researchers worldwide with powerful tools for cancer biomarker discovery, disease pathology, and precision medicine.
Research Focus
Key Achievements
Top Papers
- 1
- 2Tissue Profiling by Mass Spectrometry252 citations · 2005
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- 6Multivariable Difference Gel Electrophoresis and Mass Spectrometry41 citations · 2006
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