Jeffrey M. Spraggins
Papers
4
Total Citations
183
H-Index
4
About
Jeffrey M. Spraggins is a biomedical researcher whose work sits at the intersection of mass spectrometry imaging (MSI), proteomics, and lipid biology. He is best known for developing and refining imaging mass spectrometry (IMS) workflows that enable spatially resolved molecular mapping within biological tissues — work that has significantly advanced researchers' ability to visualize the distribution of proteins and lipids directly in tissue sections. His most-cited contribution (116 citations) demonstrated that diabetic nephropathy induces profound alterations in glomerular and tubule lipid profiles, offering crucial mechanistic insights into a devastating complication of diabetes. Beyond disease biology, Spraggins has made important methodological contributions: his work on liquid extraction surface analysis (LESA) coupled with LC for spatially targeted protein identification (39 citations) and his development of trypsin- and MALDI matrix pre-coated targets (22 citations) have streamlined sample preparation pipelines, lowering barriers for researchers adopting IMS in proteomics. His protocols for automated tissue preparation further reflect a commitment to reproducibility and accessibility. Collectively, his research has helped establish IMS as a powerful tool for uncovering molecular drivers of disease across renal pathology and beyond.
Research Focus
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Top Papers
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