Paul Kellam
Papers
2
Total Citations
71
H-Index
2
About
Paul Kellam is a leading virologist whose research sits at the intersection of viral genomics, immunology, and evolutionary biology. He is best known for his pioneering work on HIV-1, particularly in understanding how the virus evolves within hosts and populations to drive pathogenesis. A key contribution is his leadership in the BEEHIVE project (Bridging the Evolution and Epidemiology of HIV in Europe), which aims to sequence over 3,000 near-complete viral genomes to uncover the genetic determinants of HIV virulence. His work on optimizing methods for extracting HIV-1 RNA from clinical samples for high-throughput sequencing (25 citations) has been foundational for large-scale genomic surveillance. In a notable departure, Kellam has also explored unconventional antibody responses, investigating how llamas produce broadly neutralizing heavy chain-only antibodies against the HIV-1 CD4-binding site (46 citations). This work highlights his creative approach to vaccine design. With a career spanning fundamental molecular evolution to applied clinical genomics, Kellam’s research has significantly shaped our understanding of how to track, treat, and potentially prevent viral diseases.
Research Focus
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Top Papers
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