Dan Frampton
Papers
1
Total Citations
46
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1
About
Dan Frampton is a leading researcher in molecular immunology and virology, with a primary focus on the evolution of broadly neutralizing antibodies against HIV-1. His most cited work, "Molecular Evolution of Broadly Neutralizing Llama Antibodies to the CD4-Binding Site of HIV-1" (2014, 46 citations), represents a landmark contribution to the field. In this study, Frampton demonstrated that immunization of llamas can elicit heavy chain-only antibodies (HCAb) capable of broad and potent neutralization of HIV-1—a feat not previously achieved in humans or other animals. By tracing the molecular evolution of these antibodies, he provided critical insights into how the immune system can target the conserved CD4-binding site of the virus, offering a promising pathway for vaccine design. This work has been widely cited for its innovative use of camelid immunology to overcome HIV-1's notorious immune evasion. Frampton's research continues to shape our understanding of antibody maturation and the potential for novel therapeutic strategies against persistent viral infections.
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