Nisha Gupta
Papers
1
Total Citations
35
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1
About
Nisha Gupta is a molecular biologist whose research has advanced the field of cancer genomics, particularly in the detection of somatic mutations from challenging clinical specimens. Her most cited work, "Sensitive and Specific KRAS Somatic Mutation Analysis on Whole-Genome Amplified DNA from Archival Tissues" (2009, 35 citations), introduced a robust methodology for analyzing KRAS mutations—key drivers in colorectal and lung cancers—using whole-genome amplified DNA from formalin-fixed, paraffin-embedded tissues. This contribution addressed a critical bottleneck in precision oncology, enabling reliable mutation detection from archival samples where DNA is often scarce or degraded. Gupta’s approach enhanced both sensitivity and specificity, facilitating retrospective studies and biomarker validation in large patient cohorts. Her work has been instrumental in bridging the gap between routine pathology archives and high-throughput genomic analysis, supporting the development of targeted therapies. With 35 citations, this paper remains a foundational reference for researchers working on mutation analysis in archival tissues. Gupta’s expertise exemplifies how methodical innovation in molecular techniques can directly impact translational cancer research, offering practical solutions for clinical genomics.
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- 1