Nevan J. Krogan

QB3, University of California, San Francisco

Papers

Total Citations

268

H-Index

About

Nevan J. Krogan is a pioneering systems biologist whose research has fundamentally advanced our understanding of genetic interaction networks across multiple model organisms. Working at the intersection of genetics, genomics, and computational biology, Krogan has made substantial contributions to the field of functional genomics by developing and applying high-throughput methodologies to map how genes interact with one another on a massive scale. His most influential work, "High-throughput, quantitative analyses of genetic interactions in E. coli" (2008, 246 citations), demonstrated that systematic genetic interaction mapping could be extended beyond yeast to bacterial systems, opening new frontiers in our understanding of gene function and cellular organization. This foundational contribution helped establish quantitative genetic interaction mapping as an essential tool in modern biology. Building on this, his 2014 work on triple-mutant genetic interactions introduced greater analytical complexity, revealing deeper layers of cellular regulatory architecture. Krogan's laboratory has further expanded these approaches into fission yeast through the development of the Pombe Epistasis Mapper (PEM) system, creating optimized, scalable protocols for generating genetic interaction maps in *Schizosaccharomyces pombe*. Collectively, his work has equipped the research community with powerful frameworks for decoding the functional organization of genomes across diverse biological systems.