Hannes Braberg

QB3, University of California, San Francisco

Papers

Total Citations

263

H-Index

About

Hannes Braberg is a computational and systems biologist whose research focuses on deciphering the complex networks of genetic interactions that govern cellular function. His major contributions lie in developing high-throughput, quantitative methods to map how genes work together, revealing the hidden architecture of biological systems. Braberg is best known for his pioneering work on "Genetic Interaction Mapping" (GIM), a technique that enables the systematic analysis of digenic (pairwise) and even trigenic (triple-mutant) interactions in microbes. His landmark 2008 paper, "High-throughput, quantitative analyses of genetic interactions in E. coli," has garnered 246 citations, establishing a foundational framework for understanding functional relationships between genes. He further advanced the field with his 2014 study on "Quantitative analysis of triple-mutant genetic interactions," which pushed the boundaries of complexity by exploring higher-order genetic dependencies. Through these efforts, Braberg has provided powerful tools and insights that help researchers predict gene function, identify drug targets, and unravel the robustness of biological networks—work that continues to shape modern systems biology.