Assen Roguev
Papers
1
Total Citations
5
H-Index
1
About
Assen Roguev is a pioneering systems biologist whose work has fundamentally advanced our understanding of genetic interaction networks in fission yeast. His primary research focuses on high-throughput functional genomics, particularly the development and application of epistasis mapping technologies to decipher complex genetic relationships. Roguev’s most notable contribution is the creation of the Pombe Epistasis Mapper (PEM) system, a revolutionary high-throughput protocol that enables the systematic generation of double deletion mutants in *Schizosaccharomyces pombe*. This method, detailed in his widely-cited 2017 protocol, leverages the ROTOR HDA colony replicating robot to produce high-density 1536-format arrays, dramatically accelerating the pace of genetic interaction discovery. By enabling researchers to map epistatic relationships at an unprecedented scale, Roguev has provided the scientific community with a powerful tool for uncovering the functional organization of the genome. His work has laid the critical methodological groundwork for large-scale genetic interaction studies, with his protocols and systems being adopted by laboratories worldwide to explore fundamental questions in cell biology, genome stability, and disease mechanisms.
Research Focus
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