Nathalie Kucharczyk
Papers
1
Total Citations
3
H-Index
1
About
Nathalie Kucharczyk’s research centers on the design and synthesis of peptide-based libraries for drug discovery, with a particular focus on developing inhibitors of key enzymatic targets. Her most notable contribution is the pioneering work on S-farnesyltransferase inhibitors, where she led the robotic synthesis of a comprehensive 331,776-member tetrapeptide library using 24 non-natural amino acid building blocks. By employing a systematic deconvolution strategy based on HPLC-based activity assays, her team successfully identified optimized nonpeptide ligands from this vast chemical space. This work, published in 2001, demonstrated a powerful approach to transitioning from peptide leads to more drug-like small molecules, a critical step in medicinal chemistry. While her citation count is modest, the methodological innovation of her library design and screening strategy has provided a foundational framework for subsequent research in targeted inhibitor development. Her achievements highlight the importance of combinatorial chemistry and rational design in the early stages of drug discovery, making her work a valuable reference for researchers exploring farnesyltransferase as a therapeutic target.
Research Focus
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Top Papers
- 1