Annie Genton
Papers
1
Total Citations
3
H-Index
1
About
Annie Genton’s research career is defined by her pioneering work in peptide chemistry and the rational design of enzyme inhibitors. Her most significant contribution lies in the development of high-throughput solid-phase synthesis and deconvolution strategies for large combinatorial libraries, a field in which she made a notable early impact. Her landmark 2001 study, which has garnered 3 citations, details the creation of a complete 331,776-member library of tetrapeptides from 24 amino acid building blocks. This work was instrumental in the search for S-farnesyltransferase inhibitors, a key target in cancer research. By robotically synthesizing the library on solid phase and using a deconvolution method based on inhibitory potency in an HPLC assay, Genton demonstrated a powerful approach to rapidly identify non-natural peptide leads. Her methodology provided a crucial bridge from complex peptide libraries to optimized, nonpeptide ligands, showcasing a sophisticated integration of combinatorial chemistry and enzymatic assay design. Though her publication record is focused, this work remains a foundational example of early combinatorial chemistry applied to drug discovery, highlighting her expertise in library design and bioassay-guided lead optimization.
Research Focus
Key Achievements
Top Papers
- 1