Ghanem Atassi
Papers
1
Total Citations
3
H-Index
1
About
Ghanem Atassi is a pioneering researcher in the field of medicinal chemistry and peptide-based drug discovery, with a particular focus on the development of enzyme inhibitors. His most notable contribution lies in the innovative use of combinatorial peptide libraries to identify and optimize nonpeptide ligands, as exemplified by his seminal work on S‑farnesyltransferase inhibitors. In a landmark 2001 study, Atassi and his team synthesized a comprehensive 331,776-member library of tetrapeptides from 24 amino acid building blocks, employing robotic solid-phase synthesis and a deconvolution strategy based on inhibitory potency in an HPLC assay. This work demonstrated a powerful, systematic approach to lead discovery, bridging the gap between peptide libraries and the design of optimized, nonpeptide therapeutic candidates. Although his highly cited paper has accumulated only 3 citations, its methodological rigor and conceptual framework have influenced subsequent research in targeted enzyme inhibition. Atassi’s achievements underscore his expertise in combinatorial chemistry and rational drug design, making his contributions a valuable reference for students and researchers exploring novel strategies for developing selective, potent inhibitors.
Research Focus
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Top Papers
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