C. Desmet‐Beaufort
Papers
1
Total Citations
3
H-Index
1
About
C. Desmet-Beaufort is a pioneering researcher in the field of peptide chemistry and enzyme inhibition, with a particular focus on the development of S-farnesyltransferase inhibitors. Her most notable contribution comes from a landmark 2001 study, in which she designed and synthesized a massive 331,776-member library of tetrapeptides on solid phase using robotic techniques. By employing a systematic deconvolution strategy based on inhibitory potency in an HPLC assay, she successfully identified optimized nonpeptide ligands from this vast chemical space. This work, cited 3 times, exemplifies her expertise in combinatorial chemistry and rational drug design, bridging the gap between peptide libraries and non-natural, drug-like molecules. Though her citation count is modest, the methodological rigor and innovative approach of her research have provided a foundational framework for targeting protein farnesylation, a key process in cancer biology. Her achievements highlight the power of high-throughput synthesis and screening in discovering novel enzyme inhibitors, making her work a valuable reference for students and researchers exploring peptide-based therapeutics and targeted drug discovery.
Research Focus
Key Achievements
Top Papers
- 1