Natalie S. Potter

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About

Natalie S. Potter is a rising leader in the field of quantitative single-molecule microscopy, with a focused expertise in surface chemistry and biophysical imaging. Her most-cited work, "Improved Imaging Surface for Quantitative Single-Molecule Microscopy" (2024, 14 citations), introduces the RF-127 surface—a simplified passivation method that dramatically reduces nonspecific binding from protein aggregates by up to 100-fold compared to conventional approaches. This breakthrough directly addresses a critical bottleneck in sensitive, surface-based single-molecule studies, enabling more accurate quantification of molecular interactions. Potter’s contributions are pivotal for researchers studying dynamic biological processes at the nanoscale, as her surface engineering enhances signal fidelity and reproducibility. Her work has already garnered attention for its practical impact, offering a robust, accessible tool for the single-molecule community. As an emerging scholar, Potter’s achievements underscore her ability to solve fundamental challenges in microscopy, paving the way for deeper insights into molecular behavior. Her research stands as a testament to the power of innovative surface design in advancing quantitative biophysics.