Minghui Li
Papers
6
Total Citations
33
H-Index
4
About
Minghui Li is a pioneering researcher in robotic cell micromanipulation, specializing in noninvasive cellular electrophysiology and intracellular biophysics. Their work centers on developing automated robotic systems for patch clamping, intracellular pressure measurement, and cell transportation—techniques critical for understanding ion channel behavior and cellular mechanics. Li’s most notable contribution is a robotic patch clamp method that uses 3D cell morphology measurement to identify optimal gigaseal formation points, dramatically improving success rates in measuring weak ion channel signals (16 citations). They also introduced a novel robotic system for intracellular pressure measurement based on an improved balance pressure model, revealing how this physical parameter regulates cell activities and enhances micromanipulation accuracy (6 and 4 citations). Li’s innovative work extends to polar body biopsy for assisted reproductive technology, where they developed precise robotic picking techniques for nearly transparent cellular structures (4 citations), and to vision-free cell transportation using bilayer micropipettes, enabling operations without microscopic feedback (2 citations). Their recent advancement in robotic perforated patch clamping with active release control of perforating materials (1 citation) promises reduced cellular disturbance. With a growing citation impact and a focus on translating robotic precision to biological discovery, Li is shaping the future of automated cellular analysis and clinical applications.
Research Focus
Key Achievements
Top Papers
- 1
- 2Robotic Intracellular Pressure Measurement Using Micropipette Electrode6 citations · 2023
- 3
- 4Precise Robotic Picking Up of Polar Body for Biopsy Application4 citations · 2024
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- 6