Miles Congreve

Papers

Total Citations

368

H-Index

About

Miles Congreve is a leading figure in structural biology and drug discovery, best known for his pioneering work in applying structural insights to the design of novel therapeutics. His highly cited 2005 keynote review, "Structural biology and drug discovery" (340 citations), has become a foundational reference in the field, bridging the gap between molecular understanding and practical drug development. Congreve’s research focuses on G protein-coupled receptors (GPCRs), fragment-based drug design, and the integration of biophysical methods to accelerate lead identification. His early work also includes innovative contributions to automated synthesis and optimization, as demonstrated in his 2002 study on ReactArray robotics and design of experiments for supported reagent chemistry (28 citations). Beyond his publications, Congreve has made a significant impact as a co-founder of Sosei Heptares, where he has driven the discovery of multiple clinical-stage drug candidates targeting GPCRs. His achievements have earned him widespread recognition, including the American Chemical Society’s Arthur C. Cope Scholar Award. For students and researchers, Congreve exemplifies how structural biology can transform drug discovery from an empirical process into a rational, design-driven science.