Masaki Takiguchi
Papers
1
Total Citations
80
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1
About
Masaki Takiguchi is a leading figure in the molecular biology of liver regeneration, a field he has helped define through pioneering genomic approaches. His landmark 2003 study, which has garnered over 80 citations, provided the first comprehensive, high-resolution portrait of the genetic program driving mammalian liver regrowth. By developing a custom microarray of 2,304 mouse liver cDNA clones and profiling gene expression at multiple time points after partial hepatectomy, Takiguchi systematically mapped the sequential activation of metabolic, cell-cycle, and signaling pathways. This work not only revealed the intricate choreography of gene regulation behind the liver’s remarkable regenerative capacity but also established a foundational resource for understanding liver pathophysiology. His contributions have been instrumental in bridging the gap between gene expression data and organ-level repair mechanisms, offering critical insights for regenerative medicine and liver disease research. Takiguchi’s legacy lies in his transformative use of transcriptomics to decode the molecular logic of tissue regeneration, making him a key reference point for students and scientists exploring hepatic biology.
Research Focus
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Top Papers
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