Makoto Arai
Papers
1
Total Citations
80
H-Index
1
About
Makoto Arai is a leading researcher in molecular hepatology, with a primary focus on the mechanisms and pathophysiology of liver regeneration. His seminal work, "Gene Expression Profiling Reveals the Mechanism and Pathophysiology of Mouse Liver Regeneration" (2003, 80 citations), stands as a landmark contribution to the field. In this study, Arai employed a custom in-house microarray of 2,304 distinct mouse liver cDNA clones to conduct a comprehensive, time-resolved analysis of gene expression changes following partial hepatectomy. By monitoring mRNA levels up to 48 hours post-surgery, he systematically mapped the transcriptional landscape of regenerating liver tissue, identifying key regulatory pathways and molecular cascades that drive hepatic recovery. This foundational work has provided critical insights into the dynamic interplay of cell proliferation, metabolism, and signaling during liver regeneration, influencing subsequent research on liver disease and therapeutic interventions. Arai’s meticulous approach to high-throughput gene profiling has established him as a pioneer in integrating genomics with liver pathophysiology, and his findings continue to inform studies on organ repair and regenerative medicine.
Research Focus
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- 1