Martyn Hulley

Papers

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About

Martyn Hulley is a leading figure in enzyme engineering and biocatalysis, with a particular focus on the directed evolution of oxidoreductases for industrial applications. His most cited work, a 2010 study on pentaerythritol tetranitrate (PETN) reductase, exemplifies his innovative approach to accelerating biocatalyst development. In this landmark paper, Hulley pioneered an automated anaerobic kinetic screening platform that enabled the rapid, high-throughput evaluation of site-saturated libraries. By integrating a 96-well robotic system capable of recovering near-pure enzyme variants, he dramatically streamlined the directed evolution process, overcoming a major bottleneck in the field. This work has garnered 58 citations and stands as a testament to his skill in merging synthetic biology with engineering principles. Hulley’s contributions have advanced the practical use of PETN reductase in industrial biocatalysis, offering a template for the efficient evolution of other challenging enzymes. His research continues to inspire students and researchers seeking to harness directed evolution for sustainable chemical synthesis, demonstrating how automated screening can unlock the full potential of enzyme engineering.