David Mansell
Papers
1
Total Citations
58
H-Index
1
About
David Mansell is a leading figure in the field of enzyme engineering and biocatalysis, with a particular focus on the directed evolution of oxidoreductases. His most cited work, a 2010 study on pentaerythritol tetranitrate (PETN) reductase, showcases his pioneering approach to high-throughput screening. Mansell developed an automated anaerobic kinetic screening platform that enabled the rapid, 96-well format evaluation of site-saturated libraries, dramatically accelerating the identification of improved enzyme variants. This innovation, which has garnered 58 citations, addresses a critical bottleneck in directed evolution by allowing for near-pure enzyme recovery and precise kinetic characterization. By merging robotics with sophisticated anaerobic biochemistry, Mansell’s contributions have advanced the practical application of PETN reductase in industrial biocatalysis, demonstrating how automated screening can unlock the potential of enzymes for challenging synthetic transformations. His work stands as a model for integrating engineering and molecular biology to drive the evolution of more efficient and robust biocatalysts.
Research Focus
Key Achievements
Top Papers
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