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About

Mark W. Pagnano is an orthopedic surgeon and researcher whose work sits at the forefront of joint replacement surgery, with a particular focus on total knee arthroplasty (TKA) and total hip arthroplasty (THA). His research has meaningfully shaped how surgeons think about implant alignment, surgical precision, and patient outcomes in reconstructive joint surgery. Pagnano's most influential contribution examines the complex relationship between alignment strategies and patient satisfaction following TKA, a paper that has garnered an impressive 271 citations and helped redirect clinical focus toward implant positioning as both a source of and solution to postoperative dissatisfaction. His work extends into the emerging domain of robotic-assisted surgery, where he has explored how technology can overcome the inherent limitations of human performance in mechanical procedures — investigating acetabular cup positioning accuracy and the promise of robotics in achieving consistently superior outcomes in hip replacement. More recently, Pagnano has engaged with evolving controversies in the field, including debates surrounding mechanical, kinematic, and functional alignment philosophies in TKA. Across his career, his research reflects a commitment to translating technical precision into meaningful improvements for patients undergoing some of the most commonly performed orthopedic procedures worldwide.