Mario‐Ubaldo Manto

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Mario-Ubaldo Manto is a leading figure in movement disorder neuroscience, with a primary focus on cerebellar function, tremor pathophysiology, and neurorehabilitation. His work bridges fundamental mechanisms and clinical applications, notably through the development of multimodal brain-computer interfaces (BCIs) that deliver functional electrical stimulation (FES) to suppress pathological tremor. His highly cited 2010 paper on this topic (41 citations) addresses a critical unmet need: tremor affects 14.5% of people aged 50–89, and 25% of patients do not respond to medication. Manto’s contributions extend to characterizing cerebellar ataxia and refining diagnostic criteria for tremor syndromes. His research has significantly advanced understanding of how the cerebellum coordinates motor control and how its dysfunction leads to disabling movement disorders. With a career spanning decades, Manto has authored numerous influential reviews and clinical guidelines, earning recognition as a key opinion leader in neurology. His work directly impacts the design of assistive technologies and rehabilitation strategies, offering new hope for patients with drug-resistant tremor.