Marily Theodoropoulou
Papers
1
Total Citations
3
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1
About
Marily Theodoropoulou is a pioneering biophotonics researcher whose work bridges spectroscopy and clinical oncology, with a focus on developing Raman-based diagnostic tools for cancer detection. Her key research areas include tissue fixation effects on spectral signatures, tumor classification algorithms, and the integration of biobank samples into machine learning pipelines. Her major contribution lies in systematically characterizing how formalin fixation and cryofixation alter Raman spectra of human tissues, a critical step for building robust tumor classifiers using archived samples. Her 2024 study, which has already garnered 3 citations, demonstrates that while both fixation methods introduce spectral changes, they can be accounted for to enable reliable training of diagnostic models using tumor bank specimens. This work addresses a fundamental bottleneck in translating Raman spectroscopy to clinical practice—the need for large, standardized datasets. By employing a robotic Raman spectrometer to scan surgical samples pre- and post-fixation, she has established protocols that could accelerate the development of non-invasive cancer screening tools. Her research is particularly notable for its methodological rigor, directly tackling the reproducibility challenges that have hindered the clinical adoption of spectroscopic techniques.
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