Papers
2
Total Citations
139
H-Index
2
About
Manfred Koegl is a pioneer in high-throughput biology, best known for his transformative work in protein-protein interaction mapping. His research centers on the development and application of automated yeast two-hybrid (Y2H) systems, a cornerstone technology for deciphering complex cellular networks. Koegl’s most significant contribution is the large-scale, systematic screening of nuclear receptor-interacting proteins, a landmark study published in 2004 that has garnered over 124 citations. This work established a robust, automated protocol that moved Y2H screening from a manual, low-throughput technique to a powerful, hypothesis-generating engine, enabling the discovery of novel cofactors and signaling pathways. He further extended this methodology to virology, developing a high-throughput Y2H protocol specifically designed to determine virus-host protein interactions. This approach has been instrumental in revealing the molecular mechanisms of viral infection and identifying potential therapeutic targets. Through these innovations, Koegl has provided the scientific community with essential tools for exploring the interactome, solidifying his reputation as a key architect of modern functional genomics.
Research Focus
Key Achievements
Top Papers
- 1Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins124 citations · 2004
- 2