Maik Schuler
Papers
1
Total Citations
74
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1
About
Dr. Maik Schuler is a leading toxicologist whose research focuses on advancing genotoxicity testing through high-content, mechanism-based approaches. His most influential work centers on developing and validating multiplexed in vitro assays that integrate multiple biomarkers of DNA damage and cellular stress into a single, rapid flow cytometric analysis. Schuler’s landmark 2017 study, cited 74 times, describes a groundbreaking interlaboratory evaluation of a multiplexed assay that simultaneously measures p53 activation, γH2AX foci (a marker of DNA double-strand breaks), and phospho-histone H3 (a mitotic marker) in detergent-liberated nuclei. This work demonstrated exceptional reproducibility across laboratories, establishing a new standard for high-information-content genotoxicity screening that reduces false positives while providing mechanistic insight. By incorporating a known number of reference beads for absolute quantification, Schuler’s method enables precise, objective data analysis. His contributions have significantly improved the predictive power and throughput of in vitro genotoxicity assessments, directly impacting regulatory safety evaluations and pharmaceutical development. Schuler’s research bridges fundamental DNA damage biology with practical, high-throughput toxicology, making him a pivotal figure in modern genetic toxicology.
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