David Kirkland
Papers
2
Total Citations
104
H-Index
2
About
David Kirkland is a prominent researcher in the field of genetic toxicology, with particular expertise in the development and validation of in vitro genotoxicity testing methodologies. His work has significantly advanced the scientific community's ability to accurately identify chemical mutagens and clastogens while minimizing false positives that have long challenged regulatory toxicology. Kirkland has been instrumental in evaluating and refining multiplexed genotoxicity assays, most notably contributing to the validation of the MultiFlow™ DNA Damage Kit, a flow cytometry-based platform that simultaneously measures multiple biomarkers — including γH2AX, p53, and phospho-histone H3 — to discriminate between genotoxic and non-genotoxic compounds. His interlaboratory evaluation study (2017, 74 citations) demonstrated the reproducibility and reliability of this approach across multiple testing facilities, a critical milestone for regulatory acceptance. His complementary work examining promutagen discrimination in the presence of metabolic activation systems (2016, 30 citations) further strengthened the mechanistic foundation of these assays. Through rigorous collaborative research, Kirkland has helped modernize genetic toxicology testing frameworks, reducing animal use and improving predictive accuracy — contributions that continue to influence both pharmaceutical safety assessment and environmental chemical regulation worldwide.
Research Focus
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Top Papers
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