Julien Orlans

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About

Julien Orlans is a structural biologist whose work is reshaping how macromolecular crystallography (MX) is conducted at synchrotrons. His primary research focuses on developing high-throughput, automated methods for experimental phasing—a critical step in solving protein structures. Orlans’s most notable contribution, detailed in his 2020 paper “High-throughput <i>in situ</i> experimental phasing,” introduces a groundbreaking approach that leverages advanced robotics to perform multi-crystal experiments with minimal human intervention. This innovation dramatically accelerates data collection and structure determination, enabling researchers to tackle previously intractable targets. While his work has garnered 6 citations to date, its impact is already evident in the growing adoption of automated pipelines in synchrotron facilities worldwide. By streamlining the phasing process, Orlans is lowering barriers for structural biologists, particularly those studying large or weakly diffracting crystals. His achievements highlight a commitment to making MX more accessible and efficient, promising to accelerate discoveries in drug design and fundamental biology.