John E. Koundourellis

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About

John E. Koundourellis is a leading analytical chemist whose research centers on bioanalytical method development, pharmaceutical analysis, and clinical toxicology. His most impactful contribution is the validation of a novel LC-MS/MS method for quantifying colistin A and B in human plasma, a critical advance for therapeutic drug monitoring of this last-resort antibiotic. This work, which has garnered 57 citations, introduced complete automation and high-throughput sample preparation using 96-deep-well plates and robotic liquid handling—significantly improving accuracy and efficiency in clinical settings. Beyond this landmark study, Koundourellis has made substantial contributions to the analysis of antiepileptic drugs, immunosuppressants, and environmental contaminants, consistently pushing the boundaries of mass spectrometry applications. His research is characterized by rigorous validation protocols and innovative automation strategies that reduce human error and increase laboratory throughput. With a career spanning decades, Koundourellis has established himself as an authority in bioanalytical chemistry, mentoring numerous graduate students and collaborating on international projects. His work remains essential reading for researchers developing quantitative methods for complex biological matrices.