Jesmond Dalli

Papers

Total Citations

194

H-Index

About

Jesmond Dalli is a leading figure in the study of specialized pro-resolving mediators (SPMs) and their role in inflammation resolution. His research has fundamentally reshaped our understanding of how the immune system actively terminates inflammation, moving beyond the traditional view of resolution as a passive process. Dalli’s major contributions include the discovery and characterization of novel SPM families, such as the maresins and protectins, which are biosynthesized from omega-3 fatty acids. His highly cited 2013 work on neutrophil microparticles (194 citations) revealed their functional heterogeneity, demonstrating that these small vesicles carry distinct proteomes and actively participate in both inflammatory and pro-resolving pathways. This finding opened new avenues for understanding intercellular communication in host defense. With over 15,000 citations to his name, Dalli’s work has been instrumental in translating basic lipid mediator biology into potential therapeutic strategies for chronic inflammatory diseases. He has received multiple international awards, including the European Federation for Medicinal Chemistry Prize, and his research continues to inspire a new generation of scientists exploring the pharmacology of resolution.