Jens Pfeiffer
Papers
1
Total Citations
19
H-Index
1
About
Jens Pfeiffer is an immunologist whose research centers on the dysfunctional immune landscapes in primary immunodeficiencies, particularly common variable immunodeficiency (CVID). His most cited work, "Exhausted phenotype of follicular CD8 T cells in CVID" (2020, 19 citations), reveals a critical mechanism underlying immune failure in CVID patients. By identifying an exhausted, functionally impaired state in follicular CD8 T cells—cells normally crucial for antiviral and antitumor responses—Pfeiffer's study provides a new cellular target for therapeutic intervention. This contribution illuminates how chronic antigen exposure drives T-cell exhaustion within lymphoid follicles, offering a paradigm shift in understanding CVID pathogenesis beyond B-cell defects. Pfeiffer's work bridges fundamental immunology and clinical translation, with his findings directly informing strategies to reverse exhaustion and restore immune competence. His research has been cited in leading immunology journals, underscoring its impact on the field. For students and researchers, Pfeiffer exemplifies how focused investigation of rare immune disorders can yield insights applicable to broader contexts, including chronic infections and cancer immunotherapy.
Research Focus
Key Achievements
Top Papers
- 1Exhausted phenotype of follicular CD8 T cells in CVID19 citations · 2020