James H. Kaufman

United States Department of Veterans Affairs

Papers

Total Citations

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About

James H. Kaufman made significant contributions to the field of clinical biochemistry and laboratory automation during the 1960s, at a time when automated diagnostic procedures were transforming medical testing. His most influential work, "The Automated Determination of Serum Uric Acid" (1966), garnered 42 citations and introduced an innovative enzymatic procedure adaptable to both the AutoAnalyzer and the Robot Chemist platforms, measuring uric acid via the neocuproine-copper complex method. This work helped standardize and streamline a clinically important diagnostic test used in conditions such as gout and kidney disease. Kaufman further extended his expertise in laboratory automation through his paired studies on the automated determination of serum glutamic oxaloacetic transaminase (SGOT), published in 1967, which introduced a sensitive colorimetric coupling approach using the diazonium salt fast ponceau L. Though these studies attracted more modest citation counts of 7 and 6 respectively, they represented meaningful methodological advances for enzyme assay automation. Collectively, Kaufman's research helped lay groundwork for the reliable, high-throughput biochemical testing that modern clinical laboratories depend upon.