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The Automated Determination of NAD-Coupled Enzymes

Stanley Morgenstern, Richard V. Flor, Gerald Kessler, Bernard Klein

Year
1966
Citations
28
Access
Open access

Abstract

Abstract A precise automated procedure developed for determination of serum lactate dehydrogenase, using the Robot Chemist, measures absorbance of a cuprous-neo-cuproine complex formed by coupled reduction of the cupric-neocuproine reagent with enzymatically generated reduced nicotinamide adenine dinucleotide. Activity values obtained by this method, by the identical automated colorimetric method on the AutoAnalyzer, and by an automated spectrophotometric (34O-mµ) procedure show excellent agreement.

Keywords

AutoAnalyzerReagentNAD+ kinaseNicotinamide adenine dinucleotideChemistryAbsorbanceChromatographyLactate dehydrogenaseDehydrogenaseEnzyme

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