J.-Y Pabst
Papers
1
Total Citations
82
H-Index
1
About
J.-Y Pabst is a distinguished researcher in pharmaceutical bioanalysis and clinical pharmacology, with a primary focus on the stereoselective metabolism and pharmacokinetics of analgesic drugs. His most-cited work, a 2000 study on the enantiomeric determination of tramadol and its active metabolite O-desmethyltramadol in human plasma using liquid chromatography–tandem mass spectrometry (82 citations), established a foundational method for understanding the chiral behavior of this widely used opioid. This contribution has been pivotal for subsequent research on tramadol’s efficacy and safety, enabling precise quantification of its enantiomers in clinical settings. Pabst’s expertise in developing robust analytical techniques has advanced the field of therapeutic drug monitoring, particularly for drugs with complex stereochemistry. His work is frequently referenced in studies on pain management and drug metabolism, underscoring its lasting impact on both clinical practice and pharmaceutical science. Through this seminal paper, Pabst has provided a critical tool for researchers and clinicians alike, enhancing our understanding of how stereochemistry influences drug action and patient outcomes.
Research Focus
Key Achievements
Top Papers
- 1