Francis Vanderbist
Papers
1
Total Citations
82
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1
About
Francis Vanderbist is a leading figure in bioanalytical chemistry, with a primary focus on the enantioselective analysis of pharmaceutical compounds and their metabolites in biological matrices. His most impactful contribution lies in the development of a highly sensitive and specific liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for the simultaneous enantiomeric determination of tramadol and its main active metabolite, O-desmethyltramadol, in human plasma. This seminal work, published in 2000 and garnering 82 citations, provided a critical tool for pharmacokinetic studies, enabling researchers to distinguish between the distinct pharmacological activities of each enantiomer. By establishing a robust analytical framework, Vanderbist’s research has significantly advanced the understanding of chiral drug metabolism and its implications for personalized medicine. His work remains a cornerstone for scientists investigating opioid analgesics and stereoselective drug disposition, demonstrating a lasting impact on both clinical pharmacology and forensic toxicology.
Research Focus
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Top Papers
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