Hideki Hatanaka
Papers
1
Total Citations
64
H-Index
1
About
Hideki Hatanaka is a leading figure in structural biology and drug discovery, whose work bridges the gap between computational prediction and experimental validation. His primary research focuses on developing innovative strategies for identifying small-molecule ligands that bind to proteins of unknown function—a critical challenge in the postgenomic era. Hatanaka’s most influential contribution, detailed in his 2005 paper (64 citations), is a structure-based approach that combines *in silico* screening with surface plasmon resonance (SPR) measurements. This integrated methodology allows for the rapid, rational discovery of binding compounds, offering a powerful tool for functional annotation and early-stage drug development. By merging computational modeling with high-sensitivity biophysical assays, Hatanaka has provided a practical framework for tackling the vast number of uncharacterized proteins emerging from genomic projects. His work has not only advanced the field of chemical biology but also demonstrated a reproducible path from virtual hits to validated ligands. For students and researchers, Hatanaka’s research exemplifies how interdisciplinary techniques can solve fundamental problems in protein science, making his contributions essential reading for anyone interested in structure-guided drug discovery.
Research Focus
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Top Papers
- 1