Hideharu Abe
Papers
1
Total Citations
53
H-Index
1
About
Hideharu Abe’s research centers on the molecular mechanisms of diabetic nephropathy, with a particular focus on the pathological role of advanced glycation end products (AGEs) and their contribution to kidney fibrosis. In his highly cited 2004 study, Abe demonstrated that AGEs increase the expression of HSP47, a collagen-specific chaperone protein, in a mouse model of diabetic kidney disease. This work was pivotal in linking AGE-driven cellular stress to the accumulation of extracellular matrix, a hallmark of nephropathy. By showing that the AGE inhibitor OPB-9195 could suppress HSP47 and mitigate renal damage, Abe provided a mechanistic foundation for targeting chaperone proteins in diabetic complications. His research has garnered over 50 citations, reflecting its influence on both basic science and translational approaches to kidney disease. Beyond this landmark study, Abe has contributed to understanding how metabolic and oxidative stress converge on fibrotic pathways, offering insights that may lead to novel therapeutic strategies for patients with diabetes.
Research Focus
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Top Papers
- 1