Graham Duller

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About

Graham Duller is a leading figure in structural biology, specializing in the development of sample preparation and beamline technologies for macromolecular crystallography. His primary research focuses on overcoming the formidable challenges of working with microcrystals—crystals smaller than 10 micrometers—which are critical for determining the structures of challenging proteins and complexes. Duller’s major contribution is the design and implementation of a comprehensive sample preparation pipeline for microcrystals at the VMXm beamline. This pipeline integrates advanced beamline optics, beam stability, and variable beam focusing—from submicron to micron sizes—to dramatically improve data quality from these tiny, difficult-to-measure crystals. His work has been recognized in highly cited publications, with his 2021 paper on the VMXm pipeline accumulating over 10 citations, underscoring its impact on the field. By enabling researchers to obtain high-resolution diffraction data from previously inaccessible microcrystals, Duller has opened new avenues for studying biological systems at the atomic level, making him a key innovator in modern cryo-crystallography.