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Frossie Economou is a pioneering figure in astronomical cyberinfrastructure, whose work has fundamentally reshaped how telescopes, databases, and computing resources collaborate. Her research centers on intelligent observing systems, heterogeneous telescope networks, and the development of standard protocols for automated astronomy. As the lead of the eSTAR Project, Economou introduced intelligent agent technologies that enable robotic telescopes to autonomously discover resources, submit observation requests, and analyze reduced data in real-time—a system capable of data mining and cross-correlation across online catalogs. This work, cited 7 times, laid the groundwork for rapid-response astronomy. She further advanced the field by co-authoring a standard protocol for heterogeneous telescope networks (4 citations), addressing the critical need for interoperable observing services as remote and robotic observatories proliferated. Economou’s vision of linking ground-based telescopes with satellites, archives, and distributed computing clusters created autonomous decision-making software that can respond to transient events in seconds. Her contributions have been instrumental in transforming isolated telescopes into coordinated, continent-spanning smart networks, enabling a new era of time-domain astronomy.