Floris H. Groenendijk

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About

Floris H. Groenendijk is a leading figure in precision oncology, whose work centers on the clinical implementation of next-generation sequencing to transform cancer diagnostics. His most impactful contributions demonstrate the feasibility and superiority of whole genome sequencing (WGS) as a comprehensive, all-inclusive genetic test for cancer patients. In his landmark 2021 study, "Clinical Validation of Whole Genome Sequencing for Cancer Diagnostics" (86 citations), Groenendijk validated the use of WGS on fresh-frozen tissue and matched blood samples, arguing that a single test can replace the need for multiple biomarker assays—a critical advance as biopsies become smaller and the number of actionable targets grows. This work has helped shift the paradigm from targeted panels to genome-wide analysis, enabling the detection of structural variants, mutational signatures, and homologous recombination deficiency in a single workflow. By rigorously demonstrating WGS’s clinical utility, Groenendijk has paved the way for its adoption in routine diagnostics, directly impacting how oncologists personalize treatment. His research stands at the intersection of computational biology and clinical medicine, making him a key architect of the genomic revolution in cancer care.