Edwin Cuppen

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About

Edwin Cuppen is a leading figure in cancer genomics, whose work is reshaping how we diagnose and understand the disease. His primary research focuses on the clinical application of whole genome sequencing (WGS) for cancer diagnostics, aiming to replace multiple, targeted tests with a single, comprehensive analysis of a tumor’s genetic landscape. His landmark 2021 study, which has garnered 86 citations, clinically validated the use of WGS on fresh-frozen tissue and matched blood samples, demonstrating its feasibility as an all-inclusive test for detecting biomarkers. This work is particularly critical as biopsies become smaller and the need to screen for an expanding array of genetic markers grows. Beyond diagnostics, Cuppen has made profound contributions to understanding tumor evolution and mutational signatures, providing key insights into how cancers develop and acquire resistance. His research is not only advancing precision oncology but also setting the stage for a future where a single, complete genetic profile can guide treatment decisions for every cancer patient.