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Fangchen Wan pioneers the frontier of biohybrid microrobotics, engineering autonomous nanorobots that navigate the human body for precision therapy. Their research fuses materials science, synthetic biology, and nanomedicine to create motile therapeutic systems capable of subcellular intervention. Wan’s most influential work—an autonomous metal-organic framework nanorobot for active mitochondria-targeted cancer therapy (95 citations)—solved the long-standing challenge of intracellular controlled propulsion, enabling direct access to organelles for curative treatment. They further advanced the field with enzyme-powered bacterial outer membrane vesicle nanorobots (43 citations), replacing inorganic components with biocompatible, biologically functional designs. Their magnetically powered immunogenic macrophage microrobots (32 citations) introduced a multimodal cancer therapy platform that evades immune elimination while delivering targeted treatment. Demonstrating translational versatility, Wan also developed pollen typhae-based magnetic microrobots (20 citations) for acute gastric bleeding, repurposing traditional Chinese herbal medicine as a therapeutic microtool. With over 190 citations across these key works, Wan’s innovations bridge the gap between nanorobotic theory and clinical application, establishing design principles for next-generation, biologically integrated microrobots that operate at the cellular and subcellular scales.