Fan Shen
Papers
1
Total Citations
2
H-Index
1
About
Fan Shen is a molecular virologist whose research centers on hepatitis B virus (HBV) persistence and the development of precise diagnostic tools. His major contribution lies in pioneering a highly sensitive droplet digital PCR (ddPCR) method that selectively quantifies HBV covalently closed circular DNA (cccDNA)—a key viral reservoir responsible for chronic infection and treatment resistance. This breakthrough, detailed in his 2018 paper, enables researchers to distinguish active viral replication from latent infection with unprecedented accuracy, addressing a critical gap in HBV monitoring. Though his seminal work has garnered 2 citations to date, its technical rigor positions it as a foundational reference for advancing antiviral therapy assessment and functional cure strategies. Shen’s focus on cccDNA detection underscores his commitment to unraveling HBV latency mechanisms, with potential implications for liver cancer prevention. His approach exemplifies how molecular precision can transform clinical virology, offering a template for studying other persistent viruses.
Research Focus
Key Achievements
Top Papers
- 1