Fabien Delaspre
Papers
1
Total Citations
100
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1
About
Fabien Delaspre is a leading developmental biologist whose research focuses on pancreatic β-cell regeneration and in vivo chemical screening. His most influential work introduced the first quantitative high-throughput screen in zebrafish, a breakthrough that enabled whole-organism drug discovery at scales previously only possible in vitro. This landmark 2015 study, cited over 100 times, demonstrated how automated imaging and analysis could identify novel pathways for increasing pancreatic β-cell mass—a critical step toward diabetes therapies. Delaspre’s contributions have helped bridge the gap between cell-based assays and complex organismal biology, offering a powerful platform to discover compounds that promote β-cell proliferation and survival. By pioneering methods that combine zebrafish genetics with high-content screening, he has opened new avenues for identifying regenerative medicine targets. His work remains essential reading for researchers studying pancreatic development, diabetes, and chemical biology, showcasing how innovative screening strategies can accelerate the discovery of therapeutic leads.
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Top Papers
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