Alexis M. Ceasrine
Papers
1
Total Citations
100
H-Index
1
About
Alexis M. Ceasrine is a developmental and chemical biologist whose research focuses on uncovering the molecular mechanisms that govern pancreatic β-cell formation and regeneration. Her landmark 2015 study, cited over 100 times, introduced an automated high-throughput screening platform in zebrafish—the first of its kind—that enabled whole-organism chemical screens to identify novel pathways for increasing pancreatic β-cell mass. This work overcame a critical bottleneck in drug discovery by bridging the gap between in vitro assays and in vivo physiology, demonstrating that live-animal HTS is both feasible and powerful. Ceasrine’s contributions have profound implications for diabetes research, offering new avenues to identify therapeutic compounds that promote β-cell expansion. Her innovative use of zebrafish as a model system, combined with high-content imaging and automated analysis, set a new standard for in vivo chemical genetics. By pioneering scalable, organism-level screening, Ceasrine has opened doors to discovering regenerative therapies for metabolic disease, marking her as a leading voice in the quest to translate developmental biology into clinical solutions.
Research Focus
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Top Papers
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