Doron Kletter
Papers
1
Total Citations
45
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1
About
Doron Kletter is a leading researcher in cancer glycobiology, whose work focuses on the role of glycan motifs in pancreatic cancer diagnostics. His key research areas include biomarker discovery, glycomics, and the molecular characterization of tumor-secreted glycoproteins. Kletter’s major contribution lies in challenging the limitations of the standard CA19-9 biomarker, which relies on the sialyl-Lewis A (sLeA) glycan and fails to detect approximately 25% of pancreatic cancers. In his highly cited 2015 study (45 citations), he demonstrated that sLeA-low tumors secrete alternative glycans, such as sialyl-Lewis X, offering a promising new avenue for more inclusive and early cancer detection. This work has significant implications for improving diagnostic accuracy in a disease notorious for late-stage diagnosis. Kletter’s research is notable for its translational impact, directly addressing a critical gap in clinical oncology. His findings have helped reshape the understanding of glycan-based biomarkers, paving the way for multi-marker panels that could enhance early detection and patient outcomes in pancreatic cancer.
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